Chlamydia pneumoniae Stimulates IFN- Synthesis through MyD88-Dependent, TLR2- and TLR4-Independent Induction of IL-18 Release
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منابع مشابه
Chlamydia pneumoniae stimulates IFN-gamma synthesis through MyD88-dependent, TLR2- and TLR4-independent induction of IL-18 release.
Recent studies suggest that inflammation plays a central role in the pathogenesis of atherosclerosis, and IFN-gamma is a prominent proinflammatory mediator in this context. However, it is unclear what stimuli are responsible for initial stimulation of IFN-gamma synthesis in the vessel wall. In the present study, we demonstrate that Chlamydia pneumoniae is an important stimulus for IFN-gamma syn...
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Infection of murine bone marrow-derived macrophages (BMM ) with Chlamydia pneumoniae induces IFN-dependent IFNsecretion that leads to control of the intracellular bacterial growth. Enhanced growth of C. pneumoniae in Toll-like receptor (TLR) 4 / and myeloid differentiation factor (MyD) 88 / (but not TLR2 / , TLR6 / , or TLR9 / ) BMM is shown in this study. Reduced accumulation of IFNand IFNmRNA...
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